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Biologicals/ Newer treatments in Psoriasis and Psoriatic Arthritis
Biologic drugs, or “biologics,” are given by injection (shot) or intravenous (IV) infusion (a slow drip of medicine into your vein). A biologic is a protein-based drug derived from living cells cultured in a laboratory. While biologics have been used to treat disease for more than 100 years, modern-day techniques have made biologics much more widely available as treatments in the last decade.
Biologics are different from traditional systemic drugs that impact the entire immune system. Biologics, instead, target specific parts of the immune system. The biologics used to treat psoriatic disease block the action of a specific type of immune cell called a T cell, or block proteins in the immune system, such as tumor necrosis factor-alpha (TNF-alpha), interleukin 17-A, or interleukins 12 and 23. These cells and proteins all play a major role in developing psoriasis and psoriatic arthritis.
After using Methotrexate, cyclosporine and various other drugs we started using biological particularly IL-17 inhibitor secukinumab (scapho). Ten injections are given at required intervals. PASI 90 is achieved and Psoriatic Arthritis is cured. Certain other biologicals have been approved and will be shortly available in the market.